Intrinsic versus idiosyncratic drug-induced hepatotoxicity--two villains or one?

@article{Roth2010IntrinsicVI,
  title={Intrinsic versus idiosyncratic drug-induced hepatotoxicity--two villains or one?},
  author={Robert A. Roth and Patricia E. Ganey},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2010},
  volume={332 3},
  pages={959-69}
}
"Intrinsic" and "idiosyncratic" drug-induced liver injury reactions are commonly thought to arise by different modes of action. Intrinsic toxicity is reproducible in animals and occurs dose-dependently at sublethal doses. Environmental and genetic sensitivity factors can influence the toxicity of intrinsic hepatotoxicants. Among these is inflammatory stress. For example, exposure of mice to inflammatory bacterial lipopolysaccharide (LPS) causes a leftward shift in the dose-response relationship… CONTINUE READING

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