Intrinsic uncoupling of mitochondrial proton pumps. 2. Modeling studies.

@article{Pietrobon1986IntrinsicUO,
  title={Intrinsic uncoupling of mitochondrial proton pumps. 2. Modeling studies.},
  author={Daniela Pietrobon and Mario Zoratti and Giovanni Felice Azzone and S. Roy Caplan},
  journal={Biochemistry},
  year={1986},
  volume={25 4},
  pages={
          767-75
        }
}
The thermodynamic and kinetic properties associated with intrinsic uncoupling in a six-state model of a redox proton pump have been studied by computing the flow-force relations for different degrees of coupling. Analysis of these relations shows the regulatory influence of the thermodynamic forces on the extent and relative contributions of redox slip and proton slip. Inhibition has been introduced into the model in two different ways, corresponding to possible modes of action of experimental… CONTINUE READING

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