Intrinsic subtypes of high-grade bladder cancer reflect the hallmarks of breast cancer biology.

@article{Damrauer2014IntrinsicSO,
  title={Intrinsic subtypes of high-grade bladder cancer reflect the hallmarks of breast cancer biology.},
  author={Jeffrey S. Damrauer and Katherine A Hoadley and David D. Chism and Cheng Fan and Christopher J Tiganelli and Sara E Wobker and Jen Jen J. Yeh and Matthew Ivan Milowsky and Gopa Iyer and Joel S Parker and Keith Syson Chan},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 8},
  pages={
          3110-5
        }
}
We sought to define whether there are intrinsic molecular subtypes of high-grade bladder cancer. Consensus clustering performed on gene expression data from a meta-dataset of high-grade, muscle-invasive bladder tumors identified two intrinsic, molecular subsets of high-grade bladder cancer, termed "luminal" and "basal-like," which have characteristics of different stages of urothelial differentiation, reflect the luminal and basal-like molecular subtypes of breast cancer, and have clinically… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 41 REFERENCES

Prevalence and co-occurrence of actionable genomic alterations in high-grade bladder cancer.

  • Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 2013
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Cancer Genome Atlas Research Network (2013) Integrated genomic characterization of endometrial carcinoma

C Kandoth
  • Nature
  • 2013

A molecular taxonomy for urothelial carcinoma.

  • Clinical cancer research : an official journal of the American Association for Cancer Research
  • 2012

Combination of a novel gene expression signature with a clinical nomogram improves the prediction of survival in high-risk bladder cancer

M Riester
  • Clin Cancer Res
  • 2012