Intrinsic structural disorder of the C-terminal activation domain from the bZIP transcription factor Fos.

@article{Campbell2000IntrinsicSD,
  title={Intrinsic structural disorder of the C-terminal activation domain from the bZIP transcription factor Fos.},
  author={Kathleen M Campbell and Andrea R Terrell and P. J. R. Laybourn and Kevin J Lumb},
  journal={Biochemistry},
  year={2000},
  volume={39 10},
  pages={2708-13}
}
The bZIP proto-oncoprotein c-Fos activates transcription of a wide variety of genes involved in cell growth. The C-terminal activation domain of c-Fos is functionally independent of the remainder of the protein. Fos-AD corresponds to the C-terminal activation domain of human c-Fos (residues 216-380). Fos-AD suppresses (squelches) transcription in vitro, as expected for a functional activation domain lacking a DNA-binding domain. Fos-AD is unstructured and highly mobile, as demonstrated by… CONTINUE READING

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