Intrinsic sensory deprivation induced by neonatal capsaicin treatment induces changes in rat brain and behaviour of possible relevance to schizophrenia.

@article{Newson2005IntrinsicSD,
  title={Intrinsic sensory deprivation induced by neonatal capsaicin treatment induces changes in rat brain and behaviour of possible relevance to schizophrenia.},
  author={Penny N Newson and Ann Lynch-Frame and Rebecca Roach and Sarah J. V. Bennett and Vaughan J. Carr and Loris A. Chahl},
  journal={British journal of pharmacology},
  year={2005},
  volume={146 3},
  pages={408-18}
}
Schizophrenia is considered to be a neurodevelopmental disorder with origins in the prenatal or neonatal period. Brains from subjects with schizophrenia have enlarged ventricles, reduced cortical thickness (CT) and increased neuronal density in the prefrontal cortex compared with those from normal subjects. Subjects with schizophrenia have reduced pain sensitivity and niacin skin flare responses, suggesting that capsaicin-sensitive primary afferent neurons might be abnormal in schizophrenia… CONTINUE READING

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