Intrinsic resistance to apoptosis of colon epithelial cells is a potential determining factor in the susceptibility of the A/J mouse strain to dimethylhydrazine-induced colon tumorigenesis.

@article{OumounaBenachour2007IntrinsicRT,
  title={Intrinsic resistance to apoptosis of colon epithelial cells is a potential determining factor in the susceptibility of the A/J mouse strain to dimethylhydrazine-induced colon tumorigenesis.},
  author={Karine Oumouna-Benachour and Mustapha Oumouna and Mourad Zerfaoui and Chetan P Hans and Kenneth E. Fallon and A Hamid Boulares},
  journal={Molecular carcinogenesis},
  year={2007},
  volume={46 12},
  pages={
          993-1002
        }
}
Alterations in the delicate balance between cell proliferation and cell death disrupt colon homeostasis and serve as determining factors in colon tumorigenesis. The two mouse strains, AKR/J (resistant) and A/J (susceptible), have been widely used as models for dimethylhydrazine-induced colon tumorigenesis. This study examined whether the differential susceptibilities of the two mouse strains to the tumorigenic effect of dimethylhydrazine were associated with intrinsic differences in the… CONTINUE READING
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