Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy.

@article{Li2008IntrinsicRO,
  title={Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy.},
  author={Xiaoxian Li and Michael T. Lewis and Jian Huang and Carolina Gutierrez and Charles Kent Osborne and Meng-fen Wu and Susan G. Hilsenbeck and Anne C Pavlick and Xiaomei Zhang and Gary C. Chamness and Helen Wong and Jeffrey M. Rosen and Jenny C. Chang},
  journal={Journal of the National Cancer Institute},
  year={2008},
  volume={100 9},
  pages={
          672-9
        }
}
BACKGROUND Tumorigenic breast cancer cells that express high levels of CD44 and low or undetectable levels of CD24 (CD44(>)/CD24(>/low)) may be resistant to chemotherapy and therefore responsible for cancer relapse. These tumorigenic cancer cells can be isolated from breast cancer biopsies and propagated as mammospheres in vitro. In this study, we aimed to test directly in human breast cancers the effect of conventional chemotherapy or lapatinib (an epidermal growth factor receptor [EGFR]/HER2… CONTINUE READING

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