Intrinsic regulation of substrate fluxes and energy conservation in Ca2+-ATPase.

Abstract

The Ca2+-ATPase of sarcoplasmic reticulum was utilized to demonstrate an intrinsic regulation of enzyme catalysis, whereby the ratio of forward and reverse flow is altered by the binding of Ca2+ and Pi to the enzyme. This is related to displacement of internal equilibria among intermediate enzyme ligand complexes, independent of the overall equilibrium of… (More)

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@article{Meis1985IntrinsicRO, title={Intrinsic regulation of substrate fluxes and energy conservation in Ca2+-ATPase.}, author={Leopoldo de Meis and Giuseppe Inesi}, journal={FEBS letters}, year={1985}, volume={185 1}, pages={135-8} }