Intrinsic radiosensitivity and chromosome aberration analysis using fluorescence in situ hybridization in cells of two human tumor cell lines.

@article{Lambin1994IntrinsicRA,
  title={Intrinsic radiosensitivity and chromosome aberration analysis using fluorescence in situ hybridization in cells of two human tumor cell lines.},
  author={Philippe Lambin and Jos{\'e} M. Coco-Martin and J D L{\'e}gal and Adrian C. Begg and C. Parmentier and Michael C. Joiner and Edmond P. Malaise},
  journal={Radiation research},
  year={1994},
  volume={138 1 Suppl},
  pages={S40-3}
}
The survival curves for cells of two human tumor cell lines, HT29 and MeWo, have been defined using a Dynamic Microscopic Imaging Processing Scanner (DMIPS). There are two major differences between these two cell lines: (a) HT29 is more radioresistant than MeWo (surviving fraction at 2 Gy of 74 and 27%, respectively) and (b) HT29 presents a marked multiphasic survival curve with hypersensitivity at low doses (< 0.5 Gy) followed by an increase in radioresistance at higher doses which we have… CONTINUE READING