Intrinsic proinflammatory signaling in podocytes contributes to podocyte damage and prolonged proteinuria.

Abstract

Inflammation conveys the development of glomerular injury and is a major cause of progressive kidney disease. NF-κB signaling is among the most important regulators of proinflammatory signaling. Its role in podocytes, the epithelial cells at the kidney filtration barrier, is poorly understood. Here, we inhibited NF-κB signaling in podocytes by specific… (More)
DOI: 10.1152/ajprenal.00031.2012

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Cite this paper

@article{Brhler2012IntrinsicPS, title={Intrinsic proinflammatory signaling in podocytes contributes to podocyte damage and prolonged proteinuria.}, author={Sebastian Br{\"a}hler and Christina Ising and Henning Hagmann and Melanie Rasmus and Martin H{\"o}hne and Christine E. Kurschat and Tuelay Kisner and Heike Goebel and S. Martin Shankland and Klaus Addicks and Friedrich Thaiss and Bernhard Schermer and Manolis Pasparakis and Thomas Benzing and Paul Thomas Brinkkoetter}, journal={American journal of physiology. Renal physiology}, year={2012}, volume={303 10}, pages={F1473-85} }