Intrinsic potencies of novel thiol ester corticosteroids RS-85095 and RS-21314 as compared with clobetasol 17-propionate and fluocinonide.

@article{Ong1989IntrinsicPO,
  title={Intrinsic potencies of novel thiol ester corticosteroids RS-85095 and RS-21314 as compared with clobetasol 17-propionate and fluocinonide.},
  author={J. T. Ong and B. Poulsen and W. Akers and J. R. Scholtz and F. Genter and D. Kertesz},
  journal={Archives of dermatology},
  year={1989},
  volume={125 12},
  pages={
          1662-5
        }
}
  • J. T. Ong, B. Poulsen, +3 authors D. Kertesz
  • Published 1989
  • Medicine
  • Archives of dermatology
  • The intrinsic potencies of two novel topical thiol ester corticosteroids, RS-85095 and RS-21314, were compared with the high potency corticosteroids clobetasol 17-propionate and fluocinonide, using human vasoconstriction assays. In these assays, four or five concentrations (0.03 to 3 mg/L) of the corticosteroids in 95% ethanol (alcohol, USP) were applied to predetermined sites on the forearm of volunteers and were occluded following evaporation of the alcohol. The responses were scored in terms… CONTINUE READING
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    References

    SHOWING 1-10 OF 24 REFERENCES
    TOPICAL ACTIVITIES OF BETAMETHASONE ESTERS IN MAN.
    • 103
    Bioassay system for formulations of topically applied glucocorticosteroids.
    • 72
    Percutaneous Absorption of Steroids
    • 156
    Are generic formulations equivalent to trade name topical glucocorticoids?
    • 90
    Anti-inflammatory steroids without pituitary-adrenal suppression.
    • 88