Intrinsic peroxidase-like activity of ferromagnetic nanoparticles.


Nanoparticles containing magnetic materials, such as magnetite (Fe3O4), are particularly useful for imaging and separation techniques. As these nanoparticles are generally considered to be biologically and chemically inert, they are typically coated with metal catalysts, antibodies or enzymes to increase their functionality as separation agents. Here, we report that magnetite nanoparticles in fact possess an intrinsic enzyme mimetic activity similar to that found in natural peroxidases, which are widely used to oxidize organic substrates in the treatment of wastewater or as detection tools. Based on this finding, we have developed a novel immunoassay in which antibody-modified magnetite nanoparticles provide three functions: capture, separation and detection. The stability, ease of production and versatility of these nanoparticles makes them a powerful tool for a wide range of potential applications in medicine, biotechnology and environmental chemistry.

DOI: 10.1038/nnano.2007.260

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An improved way to prepare superparamagnetic magnetite– silica core –shell nanoparticles for possible biological application

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Influence of preparation parameters and characterization of nano-compound superparamagnetic iron oxide particle in dextran system

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MNPs with surface modification enhanced gene delivery of HVJ-E vector

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