Intrinsic oxidative stress causes either 2-cell arrest or cell death depending on developmental stage of the embryos from SOD1-deficient mice.

@article{Kimura2010IntrinsicOS,
  title={Intrinsic oxidative stress causes either 2-cell arrest or cell death depending on developmental stage of the embryos from SOD1-deficient mice.},
  author={Naoko Kimura and Satoshi P. Tsunoda and Yoshihito Iuchi and Hiroyuki Abe and Kiyoshi Totsukawa and Junichi Fujii},
  journal={Molecular human reproduction},
  year={2010},
  volume={16 7},
  pages={441-51}
}
Oxidative stress characterized by elevated reactive oxygen species is a well-known cause of developmental arrest and cellular fragmentation in the development of in vitro-produced embryos. To investigate the effects of intrinsic oxidative stress on the early development of embryos, oocytes from superoxide dismutase 1 (SOD1)-deficient mice resulting from in vitro fertilization, followed by culture for 4 days, were examined. Development of all embryos from SOD1-deficient oocytes was arrested at… CONTINUE READING