Intrinsic optical signals in vitro: a tool to measure alterations in extracellular space with two-dimensional resolution.

@article{Holthoff1998IntrinsicOS,
  title={Intrinsic optical signals in vitro: a tool to measure alterations in extracellular space with two-dimensional resolution.},
  author={Knut Holthoff and Otto W. Witte},
  journal={Brain research bulletin},
  year={1998},
  volume={47 6},
  pages={649-55}
}
In excitable tissues, extensive neuronal activity or pathophysiological conditions, such as spreading depression, ischemic infarct, or epileptic seizure, are accompanied by changes in extracellular space volume. Extracellular space volume, in turn, influences neuronal excitability and extracellular ion concentrations and is, therefore, an important parameter of brain activity. Unfortunately, determination of changes in extracellular space by ion-selective microelectrodes is tedious, restricted… CONTINUE READING

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