Intrinsic optical signals in rat neocortical slices measured with near-infrared dark-field microscopy reveal changes in extracellular space.

@article{Holthoff1996IntrinsicOS,
  title={Intrinsic optical signals in rat neocortical slices measured with near-infrared dark-field microscopy reveal changes in extracellular space.},
  author={Knut Holthoff and Otto W. Witte},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1996},
  volume={16 8},
  pages={2740-9}
}
In the last decade, the measurement of activity-dependent intrinsic optical signals (IOSs) in excitable tissues has become a useful tool for collecting data about spatial patterns of information processing in mammalian brain and spread of excitation. Although the extent of the IOS correlates well with the extent of electrical excitation, its time course is much slower, suggesting that it does not directly monitor the electrical activity. The aim of this study was to investigate the mechanisms… CONTINUE READING
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