Intrinsic myocyte dysfunction and tyrosine kinase pathway activation underlie the impaired wall thickening of adjacent regions during postinfarct left ventricular remodeling.

@article{Melillo1996IntrinsicMD,
  title={Intrinsic myocyte dysfunction and tyrosine kinase pathway activation underlie the impaired wall thickening of adjacent regions during postinfarct left ventricular remodeling.},
  author={Guido Melillo and Jo{\~a}o A. C. Lima and Robert M. Judd and Pascal J. Goldschmidt-Clermont and H. S. Silverman},
  journal={Circulation},
  year={1996},
  volume={93 7},
  pages={1447-58}
}
BACKGROUND Left ventricular remodeling after infarction is accompanied by dysfunction of regions adjacent to the infarct. We hypothesized that myocyte contractile abnormalities and elongation greater than in remote regions underlie adjacent-region dysfunction in the remodeled ventricle. The activation of the tyrosine kinase pathway, which mediates in vitro hypertrophy by stretch and/or angiotensin, was also assessed in myocytes separately isolated from adjacent and remote regions. METHODS AND… CONTINUE READING

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