Intrinsic limits to gene regulation by global crosstalk

  title={Intrinsic limits to gene regulation by global crosstalk},
  author={T. Friedlander and Roshan Prizak and C. Guet and N. Barton and Ga{\vs}per Tka{\vc}ik},
  journal={Nature Communications},
  • T. Friedlander, Roshan Prizak, +2 authors Gašper Tkačik
  • Published 2016
  • Biology, Physics, Medicine
  • Nature Communications
  • Gene regulation relies on the specificity of transcription factor (TF)–DNA interactions. Limited specificity may lead to crosstalk: a regulatory state in which a gene is either incorrectly activated due to noncognate TF–DNA interactions or remains erroneously inactive. As each TF can have numerous interactions with noncognate cis-regulatory elements, crosstalk is inherently a global problem, yet has previously not been studied as such. We construct a theoretical framework to analyse the effects… CONTINUE READING

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