Intrinsic limits to gene regulation by global crosstalk

@article{Friedlander2016IntrinsicLT,
  title={Intrinsic limits to gene regulation by global crosstalk},
  author={T. Friedlander and Roshan Prizak and C. Guet and N. Barton and Ga{\vs}per Tka{\vc}ik},
  journal={Nature Communications},
  year={2016},
  volume={7}
}
  • T. Friedlander, Roshan Prizak, +2 authors Gašper Tkačik
  • Published 2016
  • Biology, Physics, Medicine
  • Nature Communications
  • Gene regulation relies on the specificity of transcription factor (TF)–DNA interactions. Limited specificity may lead to crosstalk: a regulatory state in which a gene is either incorrectly activated due to noncognate TF–DNA interactions or remains erroneously inactive. As each TF can have numerous interactions with noncognate cis-regulatory elements, crosstalk is inherently a global problem, yet has previously not been studied as such. We construct a theoretical framework to analyse the effects… CONTINUE READING

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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 80 REFERENCES
    Nucleosome-mediated cooperativity between transcription factors
    • 165
    • PDF
    On schemes of combinatorial transcription logic
    • 596
    • PDF