Intrinsic kinase activity and SQ/TQ domain of Chk2 kinase as well as N-terminal domain of Wip1 phosphatase are required for regulation of Chk2 by Wip1.

@article{Yoda2006IntrinsicKA,
  title={Intrinsic kinase activity and SQ/TQ domain of Chk2 kinase as well as N-terminal domain of Wip1 phosphatase are required for regulation of Chk2 by Wip1.},
  author={Akinori Yoda and Xiao Zhou Xu and Nobuyuki Onishi and Kyoko Toyoshima and Hiroko Fujimoto and Naoko Asano Kato and Isao Oishi and Takeshi Kondo and Yasuhiro Minami},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 34},
  pages={24847-62}
}
The anti-oncogenic Chk2 kinase plays a crucial role in DNA damage-induced cell cycle checkpoint regulation. Recently, we have shown that Chk2 associates with the oncogenic Wip1 (PPM1D) phosphatase and that Wip1 acts as a negative regulator of Chk2 during DNA damage response by dephosphorylating phosphorylated Thr-68 in activated Chk2 (Fujimoto, H., Onishi, N., Kato, N., Takekawa, M., Xu, X. Z., Kosugi, A., Kondo, T., Imamura, M., Oishi, I., Yoda, A., and Minami, Y. (2006) Cell Death Differ. 13… CONTINUE READING
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