Intrinsic human immunodeficiency virus type 1 resistance of hematopoietic stem cells despite coreceptor expression.

Abstract

Interactions of human immunodeficiency virus type 1 (HIV-1) with hematopoietic stem cells may define restrictions on immune reconstitution following effective antiretroviral therapy and affect stem cell gene therapy strategies for AIDS. In the present study, we demonstrated mRNA and cell surface expression of HIV-1 receptors CD4 and the chemokine receptors… (More)

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@article{Shen1999IntrinsicHI, title={Intrinsic human immunodeficiency virus type 1 resistance of hematopoietic stem cells despite coreceptor expression.}, author={H. Shen and T. Cheng and Frederic I. Preffer and David M. Dombkowski and Michael H. Tomasson and Dan Golan and Otto O Yang and W. Hofmann and Joseph Sodroski and A. D. Luster and D. T. Scadden}, journal={Journal of virology}, year={1999}, volume={73 1}, pages={728-37} }