Intrinsic human immunodeficiency virus type 1 resistance of hematopoietic stem cells despite coreceptor expression.

@article{Shen1999IntrinsicHI,
  title={Intrinsic human immunodeficiency virus type 1 resistance of hematopoietic stem cells despite coreceptor expression.},
  author={Huangxuan Shen and T Cheng and Frederic I. Preffer and David M. Dombkowski and Michael H. Tomasson and David E. Golan and O-bong Yang and Wolfgang Hofmann and Joseph Sodroski and Andrew D Luster and David T Scadden},
  journal={Journal of virology},
  year={1999},
  volume={73 1},
  pages={728-37}
}
Interactions of human immunodeficiency virus type 1 (HIV-1) with hematopoietic stem cells may define restrictions on immune reconstitution following effective antiretroviral therapy and affect stem cell gene therapy strategies for AIDS. In the present study, we demonstrated mRNA and cell surface expression of HIV-1 receptors CD4 and the chemokine receptors CCR-5 and CXCR-4 in fractionated cells representing multiple stages of hematopoietic development. Chemokine receptor function was documented… CONTINUE READING
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