Intrinsic feedbacks in MAPK signaling cascades lead to bistability and oscillations.


Previous studies have demonstrated that double phosphorylation of a protein can lead to bistability if some conditions are fulfilled. It was also shown that the signaling behavior of a covalent modification cycle can be quantitatively and, more importantly, qualitatively modified when this cycle is coupled to a signaling pathway as opposed to being isolated… (More)
DOI: 10.1007/s10441-013-9177-5