Intrinsic factors involved in vascular smooth muscle cell proliferation in hypertension.

@article{Hadrava1991IntrinsicFI,
  title={Intrinsic factors involved in vascular smooth muscle cell proliferation in hypertension.},
  author={Vratislav Hadrava and Johanne Tremblay and Pavel Hamet},
  journal={Clinical and investigative medicine. Medecine clinique et experimentale},
  year={1991},
  volume={14 6},
  pages={535-44}
}
The exaggerated response to growth factors of vascular smooth muscle cells from spontaneously hypertensive rats when compared to cells from normotensive control Wistar-Kyoto rats persists in culture, indicating an intrinsic/genetic defect. The time course of 3H-thymidine incorporation shows that synchronized vascular smooth muscle cells from spontaneously hypertensive rats start to synthesize new DNA earlier after mitogenic stimulation than cells from normotensive rats. Flow cytometry… CONTINUE READING