Intrinsic epithelial cells repair the kidney after injury.

  title={Intrinsic epithelial cells repair the kidney after injury.},
  author={Benjamin D Humphreys and M Todd Valerius and Akio Kobayashi and Joshua W. Mugford and Savuth Soeung and Jeremy S. Duffield and Andrew P. McMahon and Joseph V. Bonventre},
  journal={Cell stem cell},
  volume={2 3},
Understanding the mechanisms of nephron repair is critical for the design of new therapeutic approaches to treat kidney disease. The kidney can repair after even a severe insult, but whether adult stem or progenitor cells contribute to epithelial renewal after injury and the cellular origin of regenerating cells remain controversial. Using genetic fate-mapping techniques, we generated transgenic mice in which 94%-95% of tubular epithelial cells, but no interstitial cells, were labeled with… CONTINUE READING
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