Intrinsic disorder in Viral Proteins Genome-Linked: experimental and predictive analyses

@article{Hbrard2009IntrinsicDI,
  title={Intrinsic disorder in Viral Proteins Genome-Linked: experimental and predictive analyses},
  author={Eug{\'e}nie H{\'e}brard and Yannick Bessin and Thierry Michon and Sonia Longhi and Vladimir N. Uversky and François Delalande and Alain van Dorsselaer and P. Romera Romero and Jocelyne Walter and Nathalie Declerk and Denis Fargette},
  journal={Virology Journal},
  year={2009},
  volume={6},
  pages={23 - 23}
}
VPgs are viral proteins linked to the 5' end of some viral genomes. Interactions between several VPgs and eukaryotic translation initiation factors eIF4Es are critical for plant infection. However, VPgs are not restricted to phytoviruses, being also involved in genome replication and protein translation of several animal viruses. To date, structural data are still limited to small picornaviral VPgs. Recently three phytoviral VPgs were shown to be natively unfolded proteins. In this paper, we… CONTINUE READING