Intrinsic differences in the proliferation of naive and memory human B cells as a mechanism for enhanced secondary immune responses.

Abstract

Humoral immune responses elicited after secondary exposure to immunizing Ag are characterized by robust and elevated reactivity of memory B cells that exceed those of naive B cells during the primary response. The mechanism underlying this difference in responsiveness of naive vs memory B cells remains unclear. We have quantitated the response of naive and… (More)

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