Intrinsic differences among spatially distinct neural crest stem cells in terms of migratory properties, fate determination, and ability to colonize the enteric nervous system.

@article{Mosher2007IntrinsicDA,
  title={Intrinsic differences among spatially distinct neural crest stem cells in terms of migratory properties, fate determination, and ability to colonize the enteric nervous system.},
  author={Jack T. Mosher and Kelly J. Yeager and Genevieve M. Kruger and Nancy M. Joseph and Mark E Hutchin and Andrzej A Dlugosz and Sean J Morrison},
  journal={Developmental biology},
  year={2007},
  volume={303 1},
  pages={1-15}
}
We have systematically examined the developmental potential of neural crest stem cells from the enteric nervous system (gut NCSCs) in vivo to evaluate their potential use in cellular therapy for Hirschsprung disease and to assess differences in the properties of postmigratory NCSCs from different regions of the developing peripheral nervous system (PNS). When transplanted into developing chicks, flow-cytometrically purified gut NCSCs and sciatic nerve NCSCs exhibited intrinsic differences in… CONTINUE READING
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