Intrinsic connectivity networks in healthy subjects explain clinical variability in Alzheimer's disease.

@article{Lehmann2013IntrinsicCN,
  title={Intrinsic connectivity networks in healthy subjects explain clinical variability in Alzheimer's disease.},
  author={Manja Lehmann and Cindee M. Madison and Pia M Ghosh and William W. Seeley and Elizabeth C. Mormino and Michael D. Greicius and Maria Luisa Gorno-Tempini and Joel H. Kramer and Bruce L. Miller and William J. Jagust and Gil D. Rabinovici},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 28},
  pages={11606-11}
}
Although previous studies have emphasized the vulnerability of the default mode network (DMN) in Alzheimer's disease (AD), little is known about the involvement of other functional networks and their relationship to clinical phenotype. To test whether clinicoanatomic heterogeneity in AD is driven by the involvement of specific networks, network connectivity was assessed in healthy subjects by seeding regions commonly and specifically atrophied in three clinical AD variants: early-onset AD (age… CONTINUE READING
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