Intrinsic connectivity network disruption in progressive supranuclear palsy.

  title={Intrinsic connectivity network disruption in progressive supranuclear palsy.},
  author={Raquel C Gardner and Adam L. Boxer and Andrew Trujillo and Jacob B. Mirsky and Christine Cong Guo and Efstathios D. Gennatas and Hilary W. Heuer and Eric Fine and Juan Zhou and Joel H. Kramer and Bruce L. Miller and William W. Seeley},
  journal={Annals of neurology},
  volume={73 5},
OBJECTIVE Progressive supranuclear palsy (PSP) has been conceptualized as a large-scale network disruption, but the specific network targeted has not been fully characterized. We sought to delineate the affected network in patients with clinical PSP. METHODS Using task-free functional magnetic resonance imaging, we mapped intrinsic connectivity to the dorsal midbrain tegmentum (dMT), a region that shows focal atrophy in PSP. Two healthy control groups (1 young, 1 older) were used to define… CONTINUE READING
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