Intrinsic clotting factors in dependency of age, sex, body mass index, and oral contraceptives: definition and risk of elevated clotting factor levels.

@article{Luxembourg2009IntrinsicCF,
  title={Intrinsic clotting factors in dependency of age, sex, body mass index, and oral contraceptives: definition and risk of elevated clotting factor levels.},
  author={Beate Luxembourg and Joern Schmitt and Marek C Humpich and Matthias Glowatzki and Erhard Seifried and Edelgard Lindhoff-Last},
  journal={Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis},
  year={2009},
  volume={20 7},
  pages={524-34}
}
Elevated clotting factors have been demonstrated to be a risk factor for venous thromboembolism (VTE). The aim of our study was to investigate the impact of age, sex, body mass index, and oral contraceptives on the clotting factor activities of factors VIII, IX, XI, and XII and their impact on the cutoff definition and risk of VTE associated with elevated clotting factors. Factor VIII, IX, XI, and XII activities were measured in 499 blood donors and 286 patients with VTE. Age and body mass… CONTINUE READING