Intrinsic calcium dynamics control botulinum toxin A susceptibility in distinct neuronal populations.

  title={Intrinsic calcium dynamics control botulinum toxin A susceptibility in distinct neuronal populations.},
  author={Carlotta Grumelli and Irene Corradini and Michela Matteoli and Claudia Verderio},
  journal={Cell calcium},
  volume={47 5},
SNAP-25 is a SNARE protein implicated in exocytosis and in the negative modulation of voltage-gated calcium channels. We have previously shown that GABAergic synapses, which express SNAP-25 at much lower levels relative to glutamatergic ones, are characterized by a higher calcium responsiveness to depolarization and are largely resistant to botulinum toxin A. We show here that silencing of SNAP-25 in glutamatergic neurons, a procedure which increases KCl-induced calcium elevations, confers… CONTINUE READING

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Coco S

C. Verderio, C. Grumelli, L. Raiteri
et al., Traffic of botulinum toxins A and E in excitatory and inhibitory neurons, Traffic. 8 • 2007
View 10 Excerpts
Highly Influenced


C. Verderio, D. Pozzi
Pravettoni, et al., SNAP-25 modulation of calcium dynamics underlies differences in GABAergic and glutamatergic responsiveness to depolarization, Neuron. 41 • 2004
View 9 Excerpts
Highly Influenced

Distribution of the SNAP 25 and SNAP 23 synaptosomalassociated protein isoforms in rat cerebellar cortex

V. Vanni G. Mandolesi, R. Cesa


J. Meng, S. V. Ovsepian
Wan, et al., Activation of TRPV1 mediates calcitonin gene-related peptide release, which excites trigeminal sensory neurons and is attenuated by a retargeted botulinum toxin with anti-nociceptive potential, J Neurosci. 29 • 2009
View 2 Excerpts


G. Mandolesi, V. Vanni
Cesa, et al., Distribution of the SNAP25 and SNAP23 synaptosomal-associated protein isoforms in rat cerebellar cortex, Neuroscience. 164 • 2009
View 1 Excerpt

Activity - dependent phosphorylation of Ser 187 is required for SNAP25negativemodulation of neuronal voltage - gated calcium channels

S. Condliffe D. Pozzi, Y. Bozzi
Proc . Natl . Acad . Sci . U . S . A . • 2008

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