Intrinsic calcium dynamics control botulinum toxin A susceptibility in distinct neuronal populations.

@article{Grumelli2010IntrinsicCD,
  title={Intrinsic calcium dynamics control botulinum toxin A susceptibility in distinct neuronal populations.},
  author={Carlotta Grumelli and Irene Corradini and Michela Matteoli and Claudia Verderio},
  journal={Cell calcium},
  year={2010},
  volume={47 5},
  pages={419-24}
}
SNAP-25 is a SNARE protein implicated in exocytosis and in the negative modulation of voltage-gated calcium channels. We have previously shown that GABAergic synapses, which express SNAP-25 at much lower levels relative to glutamatergic ones, are characterized by a higher calcium responsiveness to depolarization and are largely resistant to botulinum toxin A. We show here that silencing of SNAP-25 in glutamatergic neurons, a procedure which increases KCl-induced calcium elevations, confers… CONTINUE READING

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