Intrinsic bursting of AII amacrine cells underlies oscillations in the rd1 mouse retina.

@article{Choi2014IntrinsicBO,
  title={Intrinsic bursting of AII amacrine cells underlies oscillations in the rd1 mouse retina.},
  author={Hannah Choi and Lei Zhang and Mark S. Cembrowski and Carl F Sabottke and Alexander L Markowitz and Daniel A. Butts and William L. Kath and Joshua H. Singer and Hermann Riecke},
  journal={Journal of neurophysiology},
  year={2014},
  volume={112 6},
  pages={1491-504}
}
In many forms of retinal degeneration, photoreceptors die but inner retinal circuits remain intact. In the rd1 mouse, an established model for blinding retinal diseases, spontaneous activity in the coupled network of AII amacrine and ON cone bipolar cells leads to rhythmic bursting of ganglion cells. Since such activity could impair retinal and/or cortical responses to restored photoreceptor function, understanding its nature is important for developing treatments of retinal pathologies. Here… CONTINUE READING
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