Intrinsic basal and luminal subtypes of muscle-invasive bladder cancer

@article{Choi2014IntrinsicBA,
  title={Intrinsic basal and luminal subtypes of muscle-invasive bladder cancer},
  author={Woonyoung Choi and Bogdan A Czerniak and Andrea Ochoa and Xiaoping Su and Arlene O Siefker-Radtke and Colin P. N. Dinney and David McConkey},
  journal={Nature Reviews Urology},
  year={2014},
  volume={11},
  pages={400-410}
}
Whole-genome analyses have revealed that muscle-invasive bladder cancers (MIBCs) are heterogeneous and can be grouped into basal and luminal subtypes that are highly reminiscent of those found in breast cancer. Basal MIBCs are enriched with squamous and sarcomatoid features and are associated with advanced stage and metastatic disease at presentation. Like basal breast cancers, basal bladder tumours contain a claudin-low subtype that is enriched with biomarkers characteristic of epithelial-to… 
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TLDR
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TLDR
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TLDR
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FOXA1, GATA3 and PPARɣ Cooperate to Drive Luminal Subtype in Bladder Cancer: A Molecular Analysis of Established Human Cell Lines
TLDR
This analysis identified a set of human cell lines suitable for the study of molecular subtypes in bladder cancer, and indicates a cooperative regulatory network consisting of GATA3, FOXA1, and PPARɣ drive luminal cell fate.
Assessment of Luminal and Basal Phenotypes in Bladder Cancer
TLDR
A quantitative classifier referred to as basal to luminal transition (BLT) score is developed which identified the molecular subtypes of bladder cancer with 80–94% sensitivity and 83–93% specificity.
Exploration of genetics commonness between bladder cancer and breast cancer based on a silcio analysis on disease subtypes
TLDR
The genetics commonness between MIBC and breast cancers from the molecular heterogeneity based on the disease subtypes was explored and some basal-related and luminal-related genes shared by two cancers were identified.
Origins of Bladder Cancer.
TLDR
New research developments hold the promise of expanding the armamentarium of diagnostic and treatment options for patients with bladder cancer and improving the ability to select patients most likely to respond to a specific therapy.
Dysregulation of EMT Drives the Progression to Clinically Aggressive Sarcomatoid Bladder Cancer
TLDR
Genomic analyses revealed that SARCs are driven by downregulation of homotypic adherence genes and dysregulation of cell cycle and EMT networks, and nearly half exhibited a heavily infiltrated immune phenotype.
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