Intrinsic basal and luminal subtypes of muscle-invasive bladder cancer

  title={Intrinsic basal and luminal subtypes of muscle-invasive bladder cancer},
  author={W. Choi and B. Czerniak and Andrea Ochoa and Xiaoping Su and A. Siefker-Radtke and C. Dinney and D. McConkey},
  journal={Nature Reviews Urology},
  • W. Choi, B. Czerniak, +4 authors D. McConkey
  • Published 2014
  • Medicine
  • Nature Reviews Urology
  • Whole-genome analyses have revealed that muscle-invasive bladder cancers (MIBCs) are heterogeneous and can be grouped into basal and luminal subtypes that are highly reminiscent of those found in breast cancer. Basal MIBCs are enriched with squamous and sarcomatoid features and are associated with advanced stage and metastatic disease at presentation. Like basal breast cancers, basal bladder tumours contain a claudin-low subtype that is enriched with biomarkers characteristic of epithelial-to… CONTINUE READING
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