Intrinsic apoptotic pathways of gingival epithelial cells modulated by Porphyromonas gingivalis.

@article{Mao2007IntrinsicAP,
  title={Intrinsic apoptotic pathways of gingival epithelial cells modulated by Porphyromonas gingivalis.},
  author={Song Mao and Yoonsuk Park and Yoshiaki Hasegawa and Gena D. Tribble and Chlo{\"e} E. James and Martin Handfield and M Franci Stavropoulos and Ozlem Yilmaz and Richard J Lamont},
  journal={Cellular microbiology},
  year={2007},
  volume={9 8},
  pages={1997-2007}
}
Porphyromonas gingivalis can inhibit chemically induced apoptosis in primary cultures of gingival epithelial cells through blocking activation of the effector caspase-3. The anti-apoptotic phenotype of P. gingivalis is conserved across strains and does not depend on the presence of fimbriae, as fimbriae-deficient mutants and a naturally occurring non-fimbriated strain were able to impede apoptosis. To dissect the survival pathways modulated by P. gingivalis, protein and gene expression of a… CONTINUE READING
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