Intrinsic and extrinsic controls of the hypertrophic program of chondrocytes in the avian columella.

@article{Eavey1988IntrinsicAE,
  title={Intrinsic and extrinsic controls of the hypertrophic program of chondrocytes in the avian columella.},
  author={Roland D. Eavey and Thomas M. Schmid and Thomas F. Linsenmayer},
  journal={Developmental biology},
  year={1988},
  volume={126 1},
  pages={
          57-62
        }
}
Immunohistochemical studies of the chick columella have shown that the extracellular matrix of this ossicular cartilage template is composed largely of type II collagen. As development proceeds, synthesis of type X collagen, a hypertrophic cartilage-specific molecule, is initiated by endochondral chondrocytes within the zone of cartilage cell hypertrophy. Subsequently, these cells and their surrounding extracellular matrix are removed, resulting in marrow cavity formation. We have examined… CONTINUE READING

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