Intrinsic and extrinsic control of peripheral T-cell tolerance by costimulatory molecules of the CD28/ B7 family.

@article{BourJordan2011IntrinsicAE,
  title={Intrinsic and extrinsic control of peripheral T-cell tolerance by costimulatory molecules of the CD28/ B7 family.},
  author={H{\'e}l{\`e}ne Bour-Jordan and Jonathan H. Esensten and Marc Mart{\'i}nez-Llordella and Cristina Penaranda and Melanie Stumpf and Jeffrey A Bluestone},
  journal={Immunological reviews},
  year={2011},
  volume={241 1},
  pages={180-205}
}
Positive and negative costimulation by members of the CD28 family is critical for the development of productive immune responses against foreign pathogens and their proper termination to prevent inflammation-induced tissue damage. In addition, costimulatory signals are critical for the establishment and maintenance of peripheral tolerance. This paradigm has been established in many animal models and has led to the development of immunotherapies targeting costimulation pathways for the treatment… CONTINUE READING
Highly Influential
This paper has highly influenced a number of papers. REVIEW HIGHLY INFLUENTIAL CITATIONS