Intrinsic acyl-CoA thioesterase activity of a peroxisomal ATP binding cassette transporter is required for transport and metabolism of fatty acids.

@article{Lousa2013IntrinsicAT,
  title={Intrinsic acyl-CoA thioesterase activity of a peroxisomal ATP binding cassette transporter is required for transport and metabolism of fatty acids.},
  author={Carine de Marcos Lousa and Carlo W T van Roermund and Vincent L. G. Postis and Daniela Dietrich and Ian D Kerr and Ronald J. A. Wanders and Stephen A. Baldwin and Alison Baker and Frederica L Theodoulou},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 4},
  pages={1279-84}
}
Peroxisomes are organelles that perform diverse metabolic functions in different organisms, but a common function is β-oxidation of a variety of long chain aliphatic, branched, and aromatic carboxylic acids. Import of substrates into peroxisomes for β-oxidation is mediated by ATP binding cassette (ABC) transporter proteins of subfamily D, which includes the human adrenoleukodystropy protein (ALDP) defective in X-linked adrenoleukodystrophy (X-ALD). Whether substrates are transported as CoA… CONTINUE READING
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