Intrinsic actions of the benzodiazepine receptor antagonist Ro 15-1788

@article{File1986IntrinsicAO,
  title={Intrinsic actions of the benzodiazepine receptor antagonist Ro 15-1788},
  author={Sandra E. File and Sharon Pellow},
  journal={Psychopharmacology},
  year={1986},
  volume={88},
  pages={1-11}
}
The imidazodiazepine Ro 15-1788 is a benzodiazepine receptor antagonist that was initially reported to be lacking in intrinsic activity in a variety of test situations in which benzodiazepine-like effects can be identified. However, many recent studies have shown that this compound does indeed have intrinsic activity in a variety of behavioural, neurological, electrophysiological and biochemical preparations in both animals and man. The purpose of the present review is firstly to describe these… CONTINUE READING