Intrinsic Toxin-Derived Peptides Destabilize and Inactivate Clostridium difficile TcdB

Abstract

Clostridium difficile infection (CDI) is a major cause of hospital-associated, antibiotic-induced diarrhea, which is largely mediated by the production of two large multidomain clostridial toxins, TcdA and TcdB. Both toxins coordinate the action of specific domains to bind receptors, enter cells, and deliver a catalytic fragment into the cytosol. This… (More)
DOI: 10.1128/mBio.00503-17

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