Intrinsic Ribosome Destabilization Underlies Translation and Provides an Organism with a Strategy of Environmental Sensing.

@article{Chadani2017IntrinsicRD,
  title={Intrinsic Ribosome Destabilization Underlies Translation and Provides an Organism with a Strategy of Environmental Sensing.},
  author={Yuhei Chadani and Tatsuya Niwa and Takashi Izumi and Nobuyuki Sugata and Asuteka Nagao and Tsutomu Suzuki and Shinobu Chiba and Koreaki Ito and Hideki Taguchi},
  journal={Molecular cell},
  year={2017},
  volume={68 3},
  pages={
          528-539.e5
        }
}
Nascent polypeptides can modulate the polypeptide elongation speed on the ribosome. Here, we show that nascent chains can even destabilize the translating Escherichia coli ribosome from within. This phenomenon, termed intrinsic ribosome destabilization (IRD), occurs in response to a special amino acid sequence of the nascent chain, without involving the release or the recycling factors. Typically, a consecutive array of acidic residues and those intermitted by alternating prolines induce IRD… CONTINUE READING
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