Intrinsic Protein Disorder and Interaction Promiscuity Are Widely Associated with Dosage Sensitivity

Abstract

Why are genes harmful when they are overexpressed? By testing possible causes of overexpression phenotypes in yeast, we identify intrinsic protein disorder as an important determinant of dosage sensitivity. Disordered regions are prone to make promiscuous molecular interactions when their concentration is increased, and we demonstrate that this is the… (More)
DOI: 10.1016/j.cell.2009.04.029

Topics

Cite this paper

@article{Vavouri2009IntrinsicPD, title={Intrinsic Protein Disorder and Interaction Promiscuity Are Widely Associated with Dosage Sensitivity}, author={Tanya Vavouri and Jennifer I. Semple and Rosa Maria Garcia-Verdugo and Ben Lehner}, journal={Cell}, year={2009}, volume={138}, pages={198-208} }