Intrinsic Protein Disorder and Interaction Promiscuity Are Widely Associated with Dosage Sensitivity

@article{Vavouri2009IntrinsicPD,
  title={Intrinsic Protein Disorder and Interaction Promiscuity Are Widely Associated with Dosage Sensitivity},
  author={Tanya Vavouri and Jennifer I. Semple and Rosa Garcia-Verdugo and Ben Lehner},
  journal={Cell},
  year={2009},
  volume={138},
  pages={198-208}
}
Why are genes harmful when they are overexpressed? By testing possible causes of overexpression phenotypes in yeast, we identify intrinsic protein disorder as an important determinant of dosage sensitivity. Disordered regions are prone to make promiscuous molecular interactions when their concentration is increased, and we demonstrate that this is the likely cause of pathology when genes are overexpressed. We validate our findings in two animals, Drosophila melanogaster and Caenorhabditis… CONTINUE READING

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