Intrinsic Noise of microRNA-Regulated Genes and the ceRNA Hypothesis

@article{Noorbakhsh2013IntrinsicNO,
  title={Intrinsic Noise of microRNA-Regulated Genes and the ceRNA Hypothesis},
  author={Javad Noorbakhsh and Alex H. Lang and Pankaj Mehta},
  journal={PLoS ONE},
  year={2013},
  volume={8}
}
MicroRNAs are small noncoding RNAs that regulate genes post-transciptionally by binding and degrading target eukaryotic mRNAs. We use a quantitative model to study gene regulation by inhibitory microRNAs and compare it to gene regulation by prokaryotic small non-coding RNAs (sRNAs). Our model uses a combination of analytic techniques as well as computational simulations to calculate the mean-expression and noise profiles of genes regulated by both microRNAs and sRNAs. We find that despite very… 
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