Intrinsic ICAM-1/LFA-1 activation mediates altered responsiveness of atopic asthmatic airway smooth muscle.

Abstract

Cell adhesion molecules (CAMs) have been importantly implicated in the pathobiology of the airway responses in allergic asthma, including inflammatory cell recruitment into the lungs and altered bronchial responsiveness. To elucidate the mechanism of CAM-related mediation of altered airway responsiveness in the atopic asthmatic state, the expressions and… (More)

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@article{Grunstein2000IntrinsicIA, title={Intrinsic ICAM-1/LFA-1 activation mediates altered responsiveness of atopic asthmatic airway smooth muscle.}, author={Michael M. Grunstein and Hakon Hakonarson and N Maskeri and C H Kim and Skylar T Chuang}, journal={American journal of physiology. Lung cellular and molecular physiology}, year={2000}, volume={278 6}, pages={L1154-63} }