Intrinsic GTP hydrolysis is observed for a switch 1 variant of Cdc42 in the presence of a specific GTPase inhibitor.

@article{Morris2016IntrinsicGH,
  title={Intrinsic GTP hydrolysis is observed for a switch 1 variant of Cdc42 in the presence of a specific GTPase inhibitor.},
  author={Kyla M Morris and Rory C. Henderson and Thallapuranam Krishnaswamy Suresh Kumar and Colin D Heyes and Paul D. Adams},
  journal={Small GTPases},
  year={2016},
  volume={7 1},
  pages={1-11}
}
The Ras-related protein Cell division cycle 42 (Cdc42) is important in cell-signaling processes. Protein interactions involving Cdc42 occur primarily in flexible "Switch" regions that help regulate effector binding. We studied the kinetics of intrinsic GTP hydrolysis reaction in the absence and presence of a biologically active peptide derivative of a p21-activated kinase effector (PBD46) for wt Cdc42 and compared it to the Switch 1 variant Cdc42(T35A). While the binding of PBD46 to wt Cdc42… CONTINUE READING
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