Intrinsic Functional Plasticity of the Sensory-Motor Network in Patients with Cervical Spondylotic Myelopathy

  title={Intrinsic Functional Plasticity of the Sensory-Motor Network in Patients with Cervical Spondylotic Myelopathy},
  author={Fuqing Zhou and Y Tan and L. Wu and Ying Zhuang and L. C. He and Hong-han Gong},
  journal={Scientific Reports},
Several neuroimaging studies have suggested brain reorganisation in patients with cervical spondylotic myelopathy (CSM); however, the changes in spontaneous neuronal activity that are associated with connectedness remain largely unknown. In this study, functional connectivity strength (FCS), a data-driven degree centrality method based on a theoretical approach, was applied for the first time to investigate changes in the sensory-motor network (SMN) at the voxel level. Comparatively, CSM not… 

Abnormal intrinsic functional activity in patients with cervical spondylotic myelopathy: a resting-state fMRI study

Resting-state fMRI analyses reveal central functional reorganization in the brains of patients with cervical spondylotic myelopathy and provide complementary evidence of cortex reorganizations in these patients.

Sensorimotor cortex atrophy in patients with cervical spondylotic myelopathy

It is hypothesized that CSM causes atrophy in the sensorimotor cortices, which results in functional changes during CSM progression, which provides new insights into the compensatory reaction in CSM patients.

Altered perfusion of the sensorimotor cortex in patients with cervical spondylotic myelopathy: an arterial spin labeling study

Objective Advanced magnetic resonance imaging studies have shown functional plasticity or reorganization and metabolite alterations of N-acetyl aspartate in the sensorimotor cortex (SMC), a hallmark

Disruption of human brain connectivity networks in patients with cervical spondylotic myelopathy.

Altered functional topological organization in CSM patients may indicate sensory-motor dysfunction and blurred vision in patients with cervical spondylotic myelopathy, and the increased DMN may indicate increased psychological processing inCSM patients.

Functional Connectivity Changes of the Visual Cortex in the Cervical Spondylotic Myelopathy Patients: A Resting-State fMRI Study.

FC changes were present in the visual cortex of CSM patients, which negatively correlated with preoperative JOA scores and positively correlated withPreoperative BCVA, and significant recovery of FC in theVisual cortex was detected in CSM Patients postoperatively.

Functional cortical reorganization in cases of cervical spondylotic myelopathy and changes associated with surgery.

There is over-recruitment of sensorimotor cortices during nondexterous relative to dexterous movements before surgery and improvement in dexterity and finer movements of the upper limbs is associated with recruitment areas other than the premotor cortex to compensate for the damage in the cervical spinal cord.

Functional MRI evidence for primary motor cortex plasticity contributes to the disease’s severity and prognosis of cervical spondylotic myelopathy patients

The functional state of M1 contributes to the disease’s severity of CSM and can provide complementary information for predicting the prognosis of CSm patients following decompression surgery, indicating cortical function contributes to disease severity ofCSM.

Abnormal intrinsic brain functional network dynamics in patients with cervical spondylotic myelopathy

Investigating the dynamic functional connection of patients with CSM, focusing on the temporal characteristics of the functional connection state patterns and the variability of network topological organization, found that the mean dwell time in state 2 was significantly different between the two groups.

The Correlation between Functional Connectivity of the Primary Somatosensory Cortex and Cervical Spinal Cord Microstructural Injury in Patients with Cervical Spondylotic Myelopathy

There was synchronization between chronic cervical spinal Cord microstructural injury and cerebral cortex sensory function compensatory recombination and DTI parameters of the posterior cervical spinal cord could objectively reflect the degree of cerebral cortex sensor function impairment to a certain extent.

Regional Homogeneity and Multivariate Pattern Analysis of Cervical Spondylosis Neck Pain and the Modulation Effect of Treatment

CSNP patients are associated with dysfunction of the rTPJ and sensorimotor area, and MVPA could discriminate CSNP patients from HCs with 72% accuracy and predict clinical outcomes with a mean absolute error of 19.6%.



Cortical reorganization in patients with cervical spondylotic myelopathy.

The findings of this preliminary study demonstrate the potential of fMR imaging to assess changes in cortical representation before and after surgical intervention in patients with CSM.

Increased Low-Frequency Oscillation Amplitude of Sensorimotor Cortex Associated with the Severity of Structural Impairment in Cervical Myelopathy

A complex and diverging relationship of cortical functional reorganization and distal spinal anatomical compression in patients with CM is suggested and added important information in understanding how spinal cord integrity may be a factor in the intrinsic covariance of spontaneous low-frequency fluctuations of BOLD signals involved in cortical plasticity.

Compensatory cerebral adaptations before and evolving changes after surgical decompression in cervical spondylotic myelopathy.

Serial fMR imaging studies in CSM can capture the adaptations in specific sensorimotor cortices that accompany clinical deterioration and postsurgical improvement in sensorim motor function associated with damage and partial recovery of conduction in corticospinal pathways.

Brain reorganization in patients with spinal cord compression evaluated using fMRI

Surgical decompression results in cortical reorganization with enlarging VOA within both the PrCG and PoCG, and there were significant improvements in clinical outcomes following surgery.

Changes in Functional Magnetic Resonance Imaging Cortical Activation After Decompression of Cervical Spondylosis: Case Report

After decompressive cervical spine surgery in a patient with cervical spondylotic myelopathy, functional magnetic resonance imaging detected increased cortical activation in the primary motor cortex during finger tapping, which suggests that cortical reorganization or recruitment may accompany the recovery of function after spinal cord injury.

Proton magnetic resonance spectroscopy of the motor cortex in cervical myelopathy.

Cortical levels of N-acetylaspartate/creatine may be a meaningful biomarker in cervical myelopathy, indicative of neuronal damage or dysfunction.

Altered motor network functional connectivity in amyotrophic lateral sclerosis: a resting-state functional magnetic resonance imaging study

The results showed that the within-motor cortex FC except the within premotor area FC did not change in these early disease stage patients, which might suggest a brain mechanism to compensate the loss of the normal motor functionality in ALS.