Intrinsic Disorder in the Human Spliceosomal Proteome

@inproceedings{Korneta2012IntrinsicDI,
  title={Intrinsic Disorder in the Human Spliceosomal Proteome},
  author={Iga Korneta and Janusz M. Bujnicki},
  booktitle={PLoS Computational Biology},
  year={2012}
}
  • Iga Korneta, Janusz M. Bujnicki
  • Published in PLoS Computational Biology 2012
  • Medicine, Biology, Computer Science
  • The spliceosome is a molecular machine that performs the excision of introns from eukaryotic pre-mRNAs. This macromolecular complex comprises in human cells five RNAs and over one hundred proteins. In recent years, many spliceosomal proteins have been found to exhibit intrinsic disorder, that is to lack stable native three-dimensional structure in solution. Building on the previous body of proteomic, structural and functional data, we have carried out a systematic bioinformatics analysis of… CONTINUE READING

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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 92 REFERENCES

    UniProt Knowledgebase: a hub of integrated protein data

    VIEW 7 EXCERPTS
    HIGHLY INFLUENTIAL

    The Protein Data Bank

    VIEW 13 EXCERPTS
    HIGHLY INFLUENTIAL

    The Pfam protein families database

    VIEW 12 EXCERPTS
    HIGHLY INFLUENTIAL

    Arginine methylation an emerging regulator of protein function.

    VIEW 4 EXCERPTS
    HIGHLY INFLUENTIAL