Intrinsic Disorder and the Evolution of Viral Overlapping Genes

  title={Intrinsic Disorder and the Evolution of Viral Overlapping Genes},
  author={Pedro Jos{\'e} P{\'e}rez Romero and Corinne Rancurel and Mahvash Khosravi and A. Keith Dunker and David Karlin},
Overlapping genes result from frameshifts over pre-existing genetic sequences by a process called overprinting, yielding two or more different proteins encoded by the same nucleotides. In this situation, single base changes would frequently alter the amino acids in two or more proteins simultaneously, but such mutations would need to fit two or more sets of structural constraints. One way around such double or multiple constraints would be for overlapping genes to be enriched in structural… CONTINUE READING