Intrinsic Constraint on Plasmablast Growth and Extrinsic Limits of Plasma Cell Survival

Abstract

B cells recruited into splenic antibody responses grow exponentially, either in extrafollicular foci as plasmablasts, or in follicles where they form germinal centers. Both responses yield plasma cells. Although many splenic plasma cells survive <3 d, some live much longer. This study shows that early plasma cell death relates to a finite capacity of the… (More)

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