Intricate Crosstalk Between Lipopolysaccharide, Phospholipid and Fatty Acid Metabolism in Escherichia coli Modulates Proteolysis of LpxC

@inproceedings{Thomanek2018IntricateCB,
  title={Intricate Crosstalk Between Lipopolysaccharide, Phospholipid and Fatty Acid Metabolism in Escherichia coli Modulates Proteolysis of LpxC},
  author={Nikolas Thomanek and Jan Jippe Arends and Claudia Lindemann and Katalin Barkovits and Helmut E. Meyer and Katrin Marcus and Franz Narberhaus},
  booktitle={Front. Microbiol.},
  year={2018}
}
Lipopolysaccharides (LPS) in the outer membrane of Gram-negative bacteria provide the first line of defense against antibiotics and other harmful compounds. LPS biosynthesis critically depends on LpxC catalyzing the first committed enzyme in this process. In Escherichia coli, the cellular concentration of LpxC is adjusted in a growth rate-dependent manner by the FtsH protease making sure that LPS biosynthesis is coordinated with the cellular demand. As a result, LpxC is stable in fast-growing… CONTINUE READING
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Publications referenced by this paper.
SHOWING 1-10 OF 66 REFERENCES

Crosstalk between the lipopolysaccharide and phospholipid pathways during outer membrane biogenesis in Escherichia coli.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2016
VIEW 11 EXCERPTS
HIGHLY INFLUENTIAL

Reassessment of the genetic regulation of fatty acid synthesis in Escherichia coli: global positive control by the dual functional regulator FadR

L. My, N. Ghandour Achkar, J. P. Viala, E. Bouveret, P. de Boer
  • J. Bacteriol
  • 2015
VIEW 8 EXCERPTS
HIGHLY INFLUENTIAL

Andromeda: a peptide search engine integrated into the MaxQuant environment.

  • Journal of proteome research
  • 2011
VIEW 2 EXCERPTS
HIGHLY INFLUENTIAL