Intravitreal transforming growth factor-beta 2 decreases cellular infiltration in endotoxin-induced ocular inflammation in rabbits.

@article{Allen1996IntravitrealTG,
  title={Intravitreal transforming growth factor-beta 2 decreases cellular infiltration in endotoxin-induced ocular inflammation in rabbits.},
  author={John Bradley Allen and M. C. Mcgahan and Yoko Ogawa and Debra C. Sellon and Burton Clark and Lloyd N. Fleisher},
  journal={Current eye research},
  year={1996},
  volume={15 1},
  pages={95-103}
}
Transforming growth factor-beta (TGF-beta), a multifunctional cytokine which has been identified in normal and inflamed ocular fluids, may play a role in the evolution of inflammatory ocular lesions. In this study we utilized a rabbit model of LPS-induced uveitis to determine if exogenous TGF-beta 2 could alter its course. Recombinant TGF-beta 2 (1-2000 ng), LPS (10 or 20 ng), or TGF-beta 2 (100 ng) plus LPS (10 ng) were injected intravitreally in one eye of a New Zealand white rabbit and the… CONTINUE READING